The Study of lipid Profile and Oxidised-LDL in Type 2 Diabetes Mellitus

Aim of the study was to determine the usefulness of lipid profile& oxidized low density lipoprotein (LDL) in the identification of coronary artery disease (CAD) in Type 2 diabetes mellitus (T2DM) Lipid profile was estimated by using enzymatic methods and levels of oxidized LDL were measured by baseline diene conjugation method. Compared with control subjects, T2DM patients had higher levels of-1) Oxidized LDL (P<0.001), and the Lipid profile shows Increased levels of 2) cholesterol (p<0.001), 3) Triglycerides & VLDL (P<0.001),4) LDL-cholesterol(p<0.001) & decreased HDL cholesterol(p<0.05). The sensitivity for coronary artery disease was 81% for circulating oxidized LDL. Thus, circulating oxidized LDL is a sensitive marker of coronary artery disease. Consideration of oxidized LDL as a major risk factor and its addition to the list of established risk factors will facilitate and improve cardiovascular risk prediction to a very large extent.